Contraindications & Precautions
7-keto-DHEA may increase T3 levels.[16] People interested in starting 7-keto-DHEA supplementation, particularly those who have a thyroid disorder or who are taking thyroid hormone, should consult a physician. 7-keto-DHEA may lower blood pressure.[6] Individuals with low blood pressure should consult with a physician prior to use of this supplement.[6] At the time of writing, there were no other reported contraindications/precautions for 7-keto-DHEA. Individuals with known allergy to any of the capsule components or DHEA should not use this product.
Interactions
At the time of writing, there were no reported interactions for 7-keto-DHEA. It is possible that unknown interactions exist.
- At the time of writing, there were no reported interactions for 7-keto-DHEA. It is possible that unknown interactions exist.
- At the time of writing, there were no reported interactions for 7-keto-DHEA. It is possible that unknown interactions exist.
- At the time of writing, there were no reported interactions for 7-keto-DHEA. It is possible that unknown interactions exist.
Adverse Reactions / Side Effects
Adverse reactions and side effects of 7-keto-DHEA may include but are not limited to gastrointestinal upset/nausea, headache, decreased hemoglobin and hematocrit levels, sensitivity to mosquito bite, vertigo, and increased serum triiodothyronine (T3) levels.[6][16][17] Short-term studies in preclinical models revealed no adverse effects with 7-keto-DHEA.[20][21][22] Short-term studies in humans 7-keto-DHEA, administered as 3β-acetyl-7-oxo-DHEA, is safe and well tolerated.[6] The long-term safety of 7-keto-DHEA, in any form, or its metabolites have not been conducted. A safety study of 7-keto-DHEA administered as the acetyl ester (dose escalation: 50 mg/day for 7 days, 100 mg/day for 7 days, and 200 mg/day for 28 days) concluded that 3-acetyl-7-oxo-DHEA is safe and well tolerated.[6] In this study of 22 healthy male participants, 82% of participants in the 7-keto-DHEA group (n=16) and 100% of those in the placebo group (n=6) reported mild adverse events. The most common adverse event was gastrointestinal upset, occurring in 18% of the 7-keto-DHEA recipients and 33% of the placebo recipients. Headaches (n=4) were reported in the 7-keto-DHEA group. Two adverse events were deemed as possibly related to 7-keto-DHEA therapy, decreased hemoglobin and hematocrit levels (n=1) and heightened sensitivity to mosquito bite (n=1). Participants who received the 7-keto-DHEA acetyl ester also had significantly decreased blood pressure during treatment compared with their baseline values.[6] Nausea and vertigo and increased serum triiodothyronine (T3) levels have also been reported as adverse events and side effects, respectively, related to 7-keto-DHEA supplementation.[17][16]
Pregnancy & Breastfeeding
The safety 7-keto-DHEA has not been evaluated in pregnant women. Due to this lack of safety data, pregnant women should avoid the use of 7-keto-DHEA. The safety 7-keto-DHEA has not been evaluated in women who are breastfeeding or children. Due to this lack of safety data, women who are breastfeeding and children should avoid the use of 7-keto-DHEA.
Storage
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.
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